Jimmy Kimmel's light-hearted comedy show sees him gently ribbing his celebrity friends.
But it seems Kanye West sees nothing funny about the chatshow host.
The singer has launched an extraordinary Twitter attack on Kimmel, after finding himself the subject of one of his latenight show's spoof videos.
See Kanye Tweets;
In a no holds barred Twitter rant Kanye attacked 'out of line' Kimmel, calling him 'manipulative', insisting 'I don't take it as a joke', and attempting to rile him by adding 'your face looks crazy'.
His attack was sparked by a video screened on Tuesday night's show based on Kanye's remarkable interview with the BBC last week.
Titled Kanye Kid (Re)Kreation,the spoof saw two children act out the transcript from the interview as a 'modern take on the school play.'
In the interview Kanye revealed his opinions on everything from Lady Gaga to his opinion of himself as 'a God'.
The spoof infuriated West, who apparently took the comedy bit as an attack. He then took to Twitter to defend himself.
'Jimmy Kimmel is out of line to try and spoof in any way the piece of honest media in years,' wrote West on Thursday afternoon.
'Jimmy Kimmel, I don't take it as a joke...you don't have scum bags hopping over fences trying to take pictures of your daughter.'
apparently @KanyeWest is VERY VERY ANGRY with me....,' responded Kimmel.
A flurry of tweets occurred back and forth between to the media titans, as West began lashed out against Kimmel at neck-break speed as his tweets look a personal turn.
'You can't put yourself in my shoes. Your face looks crazy... Is that funny?... Or if I had a kid say it would it be funny???,' tweeted West.
Should I do a spoof about your face or you f*****g Ben Affleck... #NoDisrespecttoBenAffleck #AllDisrespecttoJimmyKimmell!!!!,' continued the rapper.
Kimmel responded to West's tweets calmly, staying level headed and humorous throughout the attack.
The comedian even agreed with the hip-hop artist when he attempted to insult Kimmel by claiming that his ex-girlfriend Sarah Silverman was funnier performer.
'I know! #WreckItRalph, right?,' responded Kimmel.
West then took to memes as he posted an image of Kimmel with the text 'No Good P***Y' scrawled across.
The fight took a strange turn when West tweeted a picture of SpongeBob Squarepants with the text: 'Jimmy Kimmel face motherrf*****.'
Kimmel responded: 'I swear, @kanyewest one more of these I WILL unfollow you #warning #Goshdarnit.'
And while Kanye's anger was certainly genuine, it was welcomed by Kimmel.
He later used the spat as material on Thursday night's show, reading out Kanye's tweets and joking: 'I don't understand it. I don't know why he's angry.
'But finally I'm in a rap feud! Right now we are at Death Kanye Five.'
In response to the Twitter attack, Josh Groban decided to pipe in an offer a comedic look at the situation with a skit titled 'Josh Groban's the Best Tweets of Kanya West.'
In the bit, Groban uses his golden throat to sing classic West tweets such as 'Can we please toast to the m****rf******g douchebags' and 'Fur pillows are actually hard to sleep on.'
The fictional set offers '753 original songs on 48 CDs.'
Kimmel made the following promise to his followers: 'I'll tell you the whole story about @kanyewest tonight on the show - this is not a prank, I promise (unless it's being played on me).'
'He told me I had two choices: #1. Apologize publicly...and that was really the only choice,' said the talk show host.
He then read the tweets to the studio audience.
'Finally...I'm in a rap battle!,' said Kimmel.